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To study the expression of laminin and VEGF in the peritoneal effusion (PE) of HIV-infected patients. Thirty-seven cases of HIV-infected patients with and without ascites and 10 cases of ascites were randomly collected. The total protein in the PE and plasma samples were analyzed by biuret method. The expression of laminin and VEGF in the PE and plasma were determined by sandwich enzyme linked immunosorbent assay. The total protein levels in the PE of HIV-infected patients without ascites were significantly higher than those of the control group (t = 6.621, P 0.05). The total protein level in the plasma of HIV-infected patients was also higher than that of the control group, but there was no difference between the patients with and without ascites (t = 1.390, P > 0.05). There were no significant differences in the expression of laminin and VEGF in the plasma and PE of HIV-infected patients without ascites. But